Endocrine Abstracts

Pancreatic beta cell senescence is one of the recent explanations for theincreased prevalence of type 2 diabetes in the elderly. Aging may exert a distinct influence on pancreatic β cell turnover, regeneration capacity and function. Oxidative stresses induced by metabolic stresses reduce pancreatic beta cell mass and secretion. We investigated how metabolic stresses effect on pancreatic beta cell senescence. INS-1 cells were exposed to 33mM glucose (glucotoxicity: high gl...

Beta cell senescence is being regarded as the one of the mechanisms of beta cell dysfunction. Melatonin secreted primarily from the pineal glandregulates a variety of physiological functions, such as sleep, circadian rhythms, and neuroendocrine actions. Melatonin has also very strong anti-oxidant effects. The effects of melatonin on the pancreatic beta cell senescence induced by glucolipotoxicity have not been studied. INS-1 cells were exposed to 33mM glucose with palmitate 20...

Objective: Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness. The aim of this study was to assess the association between arterial stiffness and cause specific mortality in patients with type 2 diabetes mellitus (T2DM).Methods: This multicenter prospective observational study analyzed 2,320 patients with T2DM. The patients were divided into two groups according to baPWV (cutoff baPWV of 1,750 cm/s). Causes ...